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Although a recent trial has shown to be beneficial when antiviral treatment is introduced early during the disease before hospitalization than later in the course of the disease, there is an urgent need for early therapies to reduce the risk of disease progression, prevent transmission, and be widely distributed to meet the worldwide demand (Gottlieb et al., 2022

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Kidney Insulin Clearance In the systemic circulation, besides insulin metabolization by the liver, the kidney is the major site of insulin clearance (around 25%) (Zubrod et al., 1951